From RunningPlanet.com
Each of the causes of running fatigue are separate, but they work together to make sure your body maintains sufficient strength and balance to insure both your safety and the successful completion of your goal.
Muscle Fatigue: During exercise your myofibrils can lose their ability to contract...because your muscles begin to accumulate phosphate ions, especially during sprinting events, which depresses both the sensitivity of the calcium and your muscles ability to produce force.
Metabolic Fatigue:High running speeds leads to a lot of potassium building up outside your cells, which depresses the ability of your cells to create that electrical charge. So your muscles begin to fatigue.
Energy Depletion: ...
Central Nervous System Fatigue: ...
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